The Role of Endorphins in Diseases Disease/condition References Comments Parkinsonís disease 54-56 End. control Dopamine release Hot Flashes 57, 58 Significantly lower levels of plasma beta-Endorphin were found at the onset of hot flashes as opposed to 5 - 20 minutes before Schizophrenia 59-61 The instability of Endorphin secretion may contribute to the pathogenesis of schizophrenia. Endorphins possess anti psychotic efficacy Phobias 62 Endorphin replacement has have positive effect Seizures 63-66 The lack of Endorphins correlated with a higher probability of many kinds of seizures, their injections inhibited epileptiform activities in the different regions of the brain Obesity 34, 68-71 Defects in the Endorphin system may lead to obesity Anorexia 72-74 Inhibition of Endorphin activity facilitates weight gain in nervous anorexia. Defects in the Endorphin system may lead to anorexia 67 The relaxation response of Endorphins, as well as their anti epileptic action, includes the ability to release the inhibitory neuromediator GABA PMS 75, 76 PMS had been demonstrated to correlate with endogenouse opioids system disfunction Hypertension 12, 15, 77 End decrease elevated blood pressure, but have no effects on the normotensive rats Alcoholism 78, 79 Social drinkers showed an increase of beta-Endorphin in plasma levels which on the contary was absent in dysphoric alcoholics. Diabetes 33, 80, 81 End have a stimulatory effect on insulin secretion